Retatrutide is a triple agonist peptide targeting the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R); it has demonstrated superior clinical efficacy compared to semaglutide in the treatment of obesity, obesity-related Type 2 diabetes, cardiovascular diseases, and various endocrine and metabolic disorders.

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